Epstein–Barr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide,
and viral genes are expressed in the malignant cells. EBV also very efficiently causes the …

The immune system plays critical roles in both autoimmunity and cancer, diseases at
opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance …

Enhancers determine spatiotemporal gene expression programs by engaging with long-
range promoters,,–. However, it remains unknown how enhancers find their cognate …

The science that investigates the ensembles of all peptides associated to human leukocyte
antigen (HLA) molecules is termed" immunopeptidomics" and is typically driven by mass …

The genome-wide association study (GWAS) is an effective method to detect single-
nucleotide polymorphisms (SNPs) of multiple individual genes based on linkage …

Estimating familial cancer risks is clinically important in being able to discriminate between
individuals in the population at differing risk for malignancy. To gain insight into the familial …

Common understanding suggests that the normal function of a “healthy” immune system
safe-guards and protects against the development of malignancies, whereas a genetically …

BACKGROUND Prostate cancer is the most common cancer among men in the UK. Prostate-
specific antigen testing followed by biopsy leads to overdetection, overtreatment as well as …

The tumor cells that drive classical Hodgkin lymphoma (cHL), namely, Hodgkin and Reed-
Sternberg (HRS) cells, display hallmark features that include their rareness in contrast with …

Familial aggregation of Hodgkin lymphoma (HL) has been demonstrated in large population
studies, pointing to genetic predisposition to this hematological malignancy. To understand …