Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

V Aggarwal, HS Tuli, F Thakral… - Experimental …, 2020 - journals.sagepub.com
Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-
spectrum applicability to prevent dreadful diseases such as cardiovascular disease …

Hesperidin protects liver and kidney against sodium fluoride-induced toxicity through anti-apoptotic and anti-autophagic mechanisms

C Caglayan, FM Kandemir, E Darendelioğlu… - Life Sciences, 2021 - Elsevier
Aim High dose of fluoride intake is associated with toxic effects on liver and kidney tissues.
One approach to tackle these toxicities is using natural antioxidants as supplements. This …

Flavonoids as potential therapeutics in male reproductive disorders

R Mishra, A Nikam, J Hiwarkar, T Nandgude… - Future Journal of …, 2024 - Springer
Background Male infertility presents global challenges, as current drug-based treatments
demonstrate limited effectiveness due to an incomplete understanding of dysfunctions within …

Minocycline can reduce testicular apoptosis related to varicocele in male rats

M Shokoohi, A Khaki, A Roudi Rasht Abadi… - Andrologia, 2022 - Wiley Online Library
The current research aimed to assess the impacts of Minocycline on varicocele‐induced
regulation of apoptotic‐related genes and oxidative stress in the testis of adult Wistar rats …

Sperm parameters, DNA integrity, and protamine expression in patients with type II diabetes mellitus

M Imani, AR Talebi, F Fesahat… - Journal of Obstetrics …, 2021 - Taylor & Francis
Diabetes Mellitus (DM) is the most common endocrine disorder affecting many human
physiological systems and tissues, including the reproductive organs in men. The age of …

Hesperidin mitigates cyclophosphamide-induced testicular dysfunction via altering the hypothalamic pituitary gonadal axis and testicular steroidogenesis …

T Khamis, AA Hegazy, SSA El-Fatah, ER Abdelfattah… - Pharmaceuticals, 2023 - mdpi.com
Cyclophosphamide (CP) is a cytotoxic, cell cycle, non-specific, and antiproliferative drug.
This study aimed to address the toxic effects of CP on male fertility and the possible …

Ellagic acid effects on testis, sex hormones, oxidative stress, and apoptosis in the relative sterility rat model following busulfan administration

A Rostami, S Vakili, F Koohpeyma, BN Jahromi… - … Medicine and Therapies, 2022 - Springer
Background Busulfan is an antineoplastic medication that is broadly utilized for cancer
treatment. It affects the testicular function and leads to sterility. The present study aimed to …

The palliative and antioxidant effects of hesperidin against lead-acetate-induced testicular injury in male Wistar rats

R Abu-Khudir, HH Almutairi, SS Abd El-Rahman… - Biomedicines, 2023 - mdpi.com
Lead (Pb)-induced reprotoxicity is a detrimental consequence of Pb exposure, which results
in abnormal spermatogenesis, testicular degeneration, and pathogenic sperm changes. The …

Eugenol improves tissue damage and oxidative stress in adult female rats after ovarian torsion/detorsion

B Barghi, M Shokoohi, AA Khaki, A Khaki… - Journal of Obstetrics …, 2021 - Taylor & Francis
The current study was designed to investigate the effect of eugenol on histopathological
changes and oxidative stress caused by torsion/detorsion in the ovary of adult female rats. In …

Taurine and hesperidin rescues carbon tetrachloride-triggered testicular and kidney damage in rats via modulating oxidative stress and inflammation

YM Abd-Elhakim, MH Ghoneim, LLM Ebraheim… - Life Sciences, 2020 - Elsevier
Aims: This study assessed the prophylactic or therapeutic effects of taurine (TR) and/or
hesperidin (HES) on carbon tetrachloride (CCl 4) induced acute kidney and testicular injury …