Processes to separate enantiomers

H Lorenz, A Seidel‐Morgenstern - … Chemie International Edition, 2014 - Wiley Online Library
The provision of pure enantiomers is of increasing importance not only for the
pharmaceutical industry but also for agrochemistry and biotechnology. In general, there are …

Chiral separation by enantioselective liquid–liquid extraction

B Schuur, BJV Verkuijl, AJ Minnaard… - Organic & …, 2011 - pubs.rsc.org
The literature on enantioselective liquid–liquid extraction (ELLE) spans more than half a
century of research. Nonetheless, a comprehensive overview has not appeared during the …

Experimental and modeling studies on the enantio-separation of 3, 5-dinitrobenzoyl-(R),(S)-leucine by continuous liquid–liquid extraction in a cascade of centrifugal …

B Schuur, JGM Winkelman, JG de Vries… - Chemical engineering …, 2010 - Elsevier
The continuous enantioselective liquid–liquid extraction of aqueous 3, 5-dinitrobenzoyl-
(R),(S)-leucine (AR, S) using O-(1-t-butylcarbamoyl)-11-octadecylsulfinyl-10, 11-dihydro …

Equilibrium studies on enantioselective liquid− liquid amino acid extraction using a cinchona alkaloid extractant

B Schuur, JGM Winkelman… - Industrial & engineering …, 2008 - ACS Publications
The enantioselective extraction of aqueous 3, 5-dinitrobenzoyl-R, S-leucine (AR, S) by a
cinchona alkaloid extractant (C) in 1, 2-dichloroethane was studied at room temperature …

Equilibrium studies on enantioselective extraction of oxybutynin enantiomers by hydrophilic β‐cyclodextrin derivatives

K Tang, P Zhang, C Pan, H Li - AIChE Journal, 2011 - Wiley Online Library
The enantioselective extraction of hydrophobic oxybutynin (OBN) enantiomers by
hydrophilic β‐cyclodextrin (β‐CD) derivatives was studied. The efficiency of extraction …

Continuous chiral separation of amino acid derivatives by enantioselective liquid− liquid extraction in centrifugal contactor separators

B Schuur, J Floure, AJ Hallett… - … Process Research & …, 2008 - ACS Publications
The continuous enantioselective liquid− liquid extraction of aqueous 3, 5-dinitrobenzoyl-d, l-
leucine (DNB-d, l-leu) by a cinchona alkaloid extractant (CA) in 1, 2-dichloroethane using a …

Scalable enantioseparation of amino acid derivatives using continuous liquid− liquid extraction in a cascade of centrifugal contactor separators

B Schuur, AJ Hallett, JGM Winkelman… - … Process Research & …, 2009 - ACS Publications
Using a cascade of six centrifugal contactor separators in a countercurrent liquid− liquid
extraction mode allowed the separation of one of the enantiomers of 3, 5-dinitrobenzoyl …

Single enantiomeric β-blockers—The existing technologies

J Agustian, AH Kamaruddin, S Bhatia - Process Biochemistry, 2010 - Elsevier
A number of β-blocking drugs are available in the world market, only few compounds are
found as single enantiomers. The need to use the single enantiomeric β-blockers affects …

Experimental and simulation on enantioselective extraction in centrifugal contactor separators

K Tang, H Zhang, Y Liu - AIChE Journal, 2013 - Wiley Online Library
The increasing demand for optically pure compounds stimulates the development of new
chiral separation processes on an industrial scale. The enantioselective liquid–liquid …

Enantioselective separation of R, S-phenylsuccinic acid by biphasic recognition chiral extraction

K Tang, J Yi, Y Liu, X Jiang, Y Pan - Chemical engineering science, 2009 - Elsevier
A new process has been developed to separate phenylsuccinic acid (H2A) enantiomers,
based on the oppositely preferential recognition of hydrophobic and hydrophilic chiral …