TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Oxidative stress in ozone-induced chronic lung inflammation and emphysema: a facet of chronic obstructive pulmonary disease
CH Wiegman, F Li, B Ryffel, D Togbe… - Frontiers in …, 2020 - frontiersin.org
Oxidative stress plays an important role in the pathogenesis of chronic obstructive
pulmonary disease (COPD) caused by cigarette smoke and characterized by chronic …
pulmonary disease (COPD) caused by cigarette smoke and characterized by chronic …
What is the evidence for the role of TRP channels in inflammatory and immune cells?
A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …
responses. Among these, the cation channels of the transient receptor potential (TRP) family …
New insights on the role of TRP channels in calcium signalling and immunomodulation: review of pathways and implications for clinical practice
Calcium is the most abundant mineral in the human body and is central to many
physiological processes, including immune system activation and maintenance. Studies …
physiological processes, including immune system activation and maintenance. Studies …
TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice
K Haraguchi, A Kawamoto, K Isami… - Journal of …, 2012 - Soc Neuroscience
Accumulating evidence suggests that neuroimmune interactions contribute to pathological
pain. Transient receptor potential melastatin 2 (TRPM2) is a nonselective Ca2+-permeable …
pain. Transient receptor potential melastatin 2 (TRPM2) is a nonselective Ca2+-permeable …
TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage
N Tang, W Tian, GY Ma, X Xiao, L Zhou, ZZ Li… - Nature …, 2022 - nature.com
Intracellular Ca2+ dysregulation is a key marker in septic cardiac dysfunction; however,
regulation of the classic Ca2+ regulatory modules cannot successfully abolish this symptom …
regulation of the classic Ca2+ regulatory modules cannot successfully abolish this symptom …
TRP channels: emerging targets for respiratory disease
KH Banner, F Igney, C Poll - Pharmacology & therapeutics, 2011 - Elsevier
The mammalian transient receptor potential (TRP) superfamily of cation channels is divided
into six subfamilies based on sequence homology TRPC (canonical), TRPV (vanilloid) …
into six subfamilies based on sequence homology TRPC (canonical), TRPV (vanilloid) …
TRPC6: physiological function and pathophysiological relevance
A Dietrich, T Gudermann - … Potential (TRP) Cation Channels: Volume I, 2014 - Springer
TRPC6 is a non-selective cation channel 6 times more permeable to Ca 2+ than to Na+.
Channel homotetramers heterologously expressed have a characteristic doubly rectifying …
Channel homotetramers heterologously expressed have a characteristic doubly rectifying …
Pulmonary transplantation of human induced pluripotent stem cell–derived macrophages ameliorates pulmonary alveolar proteinosis
C Happle, N Lachmann, M Ackermann… - American Journal of …, 2018 - atsjournals.org
Rationale: Although the transplantation of induced pluripotent stem cell (iPSC)–derived cells
harbors enormous potential for the treatment of pulmonary diseases, in vivo data …
harbors enormous potential for the treatment of pulmonary diseases, in vivo data …
Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production
The transient receptor potential (TRP) ion channel family is well characterized in sensory
neurons; however, little is known about its role in the immune system. Here we show that the …
neurons; however, little is known about its role in the immune system. Here we show that the …