Genetic heterogeneity between and within tumours is a major factor determining cancer
progression and therapy response. Here we examined DNA sequence and DNA copy …

Oncoproteins such as the BRAF V600E kinase endow cancer cells with malignant
properties, but they also create unique vulnerabilities. Targeting of BRAF V600E-driven …

Background Colorectal cancer (CRC) development is generally accepted as a sequential
process, with genetic mutations determining phenotypic tumor progression. However …

Simple Summary The emergence of resistant cells remains a major obstacle for
chemotherapy treatment of metastatic colorectal cancers. Improvement of the therapeutic …

Understanding the role played by genetic variations in diseases, exploring genomic variants
and discovering disease-associated loci are among the most pressing challenges of …

Background The decreasing cost of obtaining high-quality calls of genomic variants and the
increasing availability of clinically relevant data on such variants are important drivers for …

In the biomedical field, there is an ever-increasing number of large, fragmented, and isolated
data sources stored in databases and ontologies that use heterogeneous formats and poorly …

With continuous progress in science and technology, a large amount of data are produced in
all fields of the world at anytime and anywhere. These data are unmarked and lack marking …

Tremendous measure of data lakes with the exponential mounting rate is produced by the
present healthcare sector. The information from differing sources like electronic wellbeing …

Integrating heterogeneous biological databases for unveiling the new intra-molecular and
inter-molecular attributes, behaviors, and relationships in the human cellular system has …