Optical imaging in the near-infrared (NIR) range enables detecting ligand-receptor
interactions and enzymatic activity in vivo due to lower scattering and absorption of NIR …

We describe the design, synthesis and fluorescence profiles of new self-calibrating viscosity
dyes in which a coumarin (reference fluorophore) has been covalently linked with a …

Short oligonucleotide sequences are now being widely investigated for their potential
therapeutic properties. The modification of oligonucleotide termini with short fluorinated …

There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular
penetration due to their polyanionic nature is a major obstacle. We addressed this problem …

Two types of reporters for optical sensing of NF-κB p50 protein-oligodeoxyribonucleotide
(ODN) duplex interactions were designed and compared in vitro. The reporters were based …

The molecular recognition of carbohydrates and proteins mediates a wide range of
physiological processes and the development of synthetic carbohydrate receptors …

Three oligodeoxyribonucleotides (ODN) covalently labeled with near-infrared (NIR)
fluorochromes were synthesized and characterized with a goal of comparing in vitro a …

Early pro-inflammatory signaling in the endocrine pancreas involves activation of NF-κB,
which is believed to be important for determining the ultimate fate of β− cells and hence …

We designed and synthesized sensors for imaging transcription factor–DNA interactions
using a complementary pair of 21-base pair long oligonucleotides (ODNs) carrying two …

We report a general phenomenon of the formation of either a fluorescent or an entirely
quenched oligodeoxynucleotide (ODN) duplex system by hybridizing pairs of …