Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of
heterotrimeric G proteins on the membrane and then activate downstream signaling …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular
environment of cells and degrade both matrix and non-matrix proteins. They play central …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

The biological roles of the matrix metalloproteinases (MMPs) have been traditionally
associated with the degradation and turnover of most of the components of the extracellular …

The balance between matrix metalloproteinases (MMPs) and their inhibitors, the tissue
inhibitors of metalloproteinases (TIMPs), is largely responsible for the remodeling of tissues …

Intimal thickening occurs in blood vessels in response to injury or atherosclerosis. The
balance of migration and proliferation of vascular smooth muscle cells (VSMC) over death …

Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …