Acute myocardial infarction causes lethal injury to cardiomyocytes during both ischaemia
and reperfusion (IR). It is important to define the precise mechanisms by which they die in …

Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In
particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby …

Purpose Myocardial ischemic reperfusion injury (MIRI) is a crucial clinical problem globally.
The molecular mechanisms of MIRI need to be fully explored to develop new therapeutic …

Cardiovascular disease (CVD) is the leading cause of death in the global population,
accounting for about one-third of all deaths each year. Notably, with CVDs, myocardial …

Aims Regulated necrosis (necroptosis) and apoptosis are important biological features of
myocardial infarction, ischaemia-reperfusion (I/R) injury, and heart failure. However, the …

The phenomenon of ischemic preconditioning has been recognized as one of the most
potent mechanisms to protect against myocardial ischemic injury. In experimental animals …

Reperfusion is the definitive treatment to salvage ischemic myocardium from infarction. A
primary determinant of infarct size is the duration of ischemia. In myocardium that has not …

Aims Estrogen plays an important role in cardioprotection. Animal experiments showed that
the G-protein coupled estrogen receptor 30 (GPR30) specific agonist G1 could reduce post …

Cardiovascular diseases are the leading cause of death globally, among which acute
myocardial infarction (AMI) frequently occurs in the heart and proceeds from myocardium …

The effectiveness of the rehabilitative benefits of physical exercise appears to be contingent
upon when the exercise is initiated after stroke. The present study assessed the hypothesis …