Fluorescence in situ hybridization (FISH) is an effective technique for localizing cloned DNA
probes directly onto metaphase chromosomes. Human genome mapping using FISH has …

Many different chromosomal races with reduced chromosome number due to the presence
of Robertsonian fusion metacentrics have been described in western Europe and northern …

The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to
authentic DNA cytosine methyltransferases. A combined genetic and biochemical approach …

DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to
specific sequences to induce or repress gene expression. Comparative genomics has …

Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the
processes that trigger cellular responses to telomere dysfunction, we crossed mTR−/− G6 …

Mammalian genomes employ heritable cytosine methylation in the long-term silencing of
retrotransposons and genes subject to genomic imprinting and X chromosome inactivation …

We report the interaction between a human centromere antigen and an alphoid DNA, a
human centromeric satellite DNA, which consists of 170-bp repeating units. A cloned …

TELOMERE structure and behaviour is less well understood in vertebrates than it is in
ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic chromosomes, those of …

Centromere protein A (Cenpa for mouse, CENP-A for other species) is a histone H3-like
protein that is thought to be involved in the nucleosomal packaging of centromeric DNA …

Genomic reprogramming of primordial germ cells (PGCs), which includes genome‐wide
demethylation, prevents aberrant epigenetic modifications from being transmitted to …