Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

The nature of depression has recently been reconceptualized, being conceived as the
clinical expression of activated immune-inflammatory, oxidative, and nitrosative stress …

Targeted immunomodulation of dendritic cells (DCs) in vivo will enable manipulation of T-
cell priming and amplification of anticancer immune responses, but a general strategy has …

Simple Summary Cancer immunotherapy is a breakthrough in cancer treatment.
Unfortunately, despite the encouraging results in clinical treatment, cancer immunotherapy …

The innate immune system consists of a variety of elements controlling and participating in
virtually all aspects of inflammation and immunity. It is crucial for host defense, but on the …

Since tyrosine phosphorylation is reversible and dynamic in vivo, the phosphorylation state
of proteins is controlled by the opposing roles of protein tyrosine kinases (PTKs) and protein …

Gastric cancer (GC) is the fifth most common malignancy in the world. The major cause of
GC is chronic infection with Helicobacter pylori (H. pylori). Infection with H. pylori leads to an …

Epithelial-mesenchymal transition (EMT) is thought to contribute to metastasis and
chemoresistance in patients with hepatocellular carcinoma (HCC), leading to their poor …

Paxillin (PXN) is a cytoplasmic protein that plays an important role in regulating focal
adhesion, cytoskeletal rearrangements and cell motility. The present study aimed to …

During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic
endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate …