Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities

R Rabbie, P Ferguson, C Molina‐Aguilar… - The Journal of …, 2019 - Wiley Online Library
Melanoma is characterised by its ability to metastasise at early stages of tumour
development. Current clinico‐pathologic staging based on the American Joint Committee on …

[HTML][HTML] Skin cancer epidemics in the elderly as an emerging issue in geriatric oncology

S Garcovich, G Colloca, P Sollena, B Andrea… - Aging and …, 2017 - ncbi.nlm.nih.gov
Skin cancer is a worldwide, emerging clinical need in the elderly white population, with a
steady increase in incidence rates, morbidity and related medical costs. Skin cancer is a …

Adjuvant vemurafenib in resected, BRAFV600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

M Maio, K Lewis, L Demidov, M Mandalà… - The Lancet …, 2018 - thelancet.com
Background Systemic adjuvant treatment might mitigate the high risk of disease recurrence
in patients with resected stage IIC–III melanoma. The BRIM8 study evaluated adjuvant …

[HTML][HTML] Prediction and monitoring of relapse in stage III melanoma using circulating tumor DNA

L Tan, S Sandhu, RJ Lee, J Li, J Callahan, S Ftouni… - Annals of …, 2019 - Elsevier
Background The advent of effective adjuvant therapies for patients with resected melanoma
has highlighted the need to stratify patients based on risk of relapse given the cost and …

From conventional therapies to immunotherapy: melanoma treatment in review

L Kuryk, L Bertinato, M Staniszewska, K Pancer… - Cancers, 2020 - mdpi.com
Simple Summary Here, we review the current state of knowledge in the field of cancer
immunotherapy, focusing on the scientific rationale for the use of oncolytic viruses …

[HTML][HTML] Tumor infiltrating lymphocytes: The regulator of melanoma evolution

M Antohe, RI Nedelcu, L Nichita… - Oncology …, 2019 - … .spandidos-publications.com
Melanoma is the most severe type of skin cancer and its incidence has increased in the last
decades. In the United States, it is the 6th most common cancer in both men and women …

Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients

JS Zager, BR Gastman, S Leachman, RC Gonzalez… - BMC cancer, 2018 - Springer
Background The heterogeneous behavior of patients with melanoma makes prognostication
challenging. To address this, a gene expression profile (GEP) test to predict metastatic risk …

[HTML][HTML] CX3CR1 identifies PD-1 therapy–responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy

Y Yan, S Cao, X Liu, SM Harrington, WE Bindeman… - JCI insight, 2018 - ncbi.nlm.nih.gov
Although immune checkpoint inhibitors have resulted in durable clinical benefits in a subset
of patients with advanced cancer, some patients who did not respond to initial anti–PD-1 …

Paclitaxel-loaded macrophage membrane camouflaged albumin nanoparticles for targeted cancer therapy

X Cao, T Tan, D Zhu, H Yu, Y Liu, H Zhou… - International journal …, 2020 - Taylor & Francis
Background Melanoma is the most common symptom of aggressive skin cancer, and it has
become a serious health concern worldwide in recent years. The metastasis rate of …

MiR-497-5p, miR-195-5p and miR-455-3p function as tumor suppressors by targeting hTERT in melanoma A375 cells

L Chai, XJ Kang, ZZ Sun, MF Zeng, SR Yu… - Cancer management …, 2018 - Taylor & Francis
Background hTERT gene plays an important role in melanoma, although the specific
mechanism involved is unclear. The aim of this study was to screen and identify the relative …