Millions of people are affected by visual impairment and blindness globally, and the
prevalence of vision loss is likely to increase as we are living longer. However, many ocular …

INTRODUCTION During embryogenesis, pluripotent cells gradually become specialized
and acquire distinct functions and morphologies. Because much of the specification process …

Visual impairment and blindness is widespread across the human population, and the
development of therapies for ocular pathologies is of high priority. The zebrafish represents …

Excess retinoids as well as retinoid deprivation cause abnormal development, suggesting
that retinoid homeostasis is critical for proper morphogenesis. RALDH-2 and CYP26, two …

Preplacodal ectoderm arises near the end of gastrulation as a narrow band of cells
surrounding the anterior neural plate. This domain later resolves into discrete cranial …

The ascending thoracic aorta is designed to withstand biomechanical forces from pulsatile
blood. Thoracic aortic aneurysms and acute aortic dissections (TAADs) occur as a result of …

Mutations in the transcription factor genes FOXE3, HSF4, MAF, and PITX3 cause congenital
lens defects including cataracts that may be accompanied by defects in other components of …

The lens was the first tissue in which the concept of embryonic induction was demonstrated.
For many years lens induction was thought to occur at the time the optic vesicle and lens …

Visual impairment and blindness are common and seriously affect people's work and quality
of life in the world. Therefore, the effective therapies for eye diseases are of high priority …

Development of the anterior segment of the eye requires reciprocal sequential interactions
between the arising tissues, facilitated by numerous genetic factors. Disruption of any of …