Multidrug resistance (MDR) in cancer chemotherapy is a growing concern for medical
practitioners. P-glycoprotein (P-gp) overexpression is one of the major reasons for multidrug …

Hypoxia is a common feature of the tumor microenvironment, which is characterized by
tissue oxygen deficiency due to an aggressive proliferation of cancer cells. Hypoxia …

Chemotherapy plays an important role in treating cancers in clinic. Hypoxia‐mediated
chemoresistance remains a major hurdle for effective tumor chemotherapy. Herein, a new …

In tissue engineering, excessively generated reactive oxygen species (ROS) during
biomaterial implantation or cell transplantation is a one of major causes of diminishing …

Hypoxia is a hallmark of solid tumors and it significantly contributes to the development of
key biological features of tumors, including the microenvironment, migration, invasion …

Transition metal catalysts (TMCs) mediated bioorthogonal uncaging catalysis has sparked
increasing interest in prodrug activation. However, due to their “always‐on” catalytic activity …

Many central nervous system (CNS) diseases are still incurable and only symptomatic
treatments are available. Oxidative stress is suggested to be a common hallmark, being able …

The tumor microenvironment (TME), as an immunosuppressive milieu, has a critical role in
tumor progression and increases resistance to the conventional treatments. Among the …

Highlights•A systematic review on how new generation molecular nanomedicine allows
chemoresistant cancer management.•Recent developments in molecular targeting …

Over the past five years, oxygen-based nanocarriers (NCs) to boost anti-tumor therapy
attracted tremendous attention from basic research and clinical practice. Indeed, tumor …