The human transcriptome is composed of a vast RNA population that undergoes further
diversification by splicing. Detecting specific splice sites in this large sequence pool is the …

Alternative splicing allows for the expression of multiple RNA and protein isoforms from one
gene, making it a major contributor to transcriptome and proteome diversification in …

Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome,
which removes> 99% of introns, and the minor spliceosome, which removes rare …

Research on non‐coding RNA (nc RNA) is a rapidly expanding field. Providing an official
gene symbol and name to nc RNA genes brings order to otherwise potential chaos as it …

Splicing factors are affected by recurrent somatic mutations and copy number variations in
several types of haematologic and solid malignancies, which is often seen as prima facie …

Most small non-coding RNAs (sncRNAs) with regulatory functions are encoded by majority
sequences in the human genome, and the emergence of high-throughput sequencing …

Removal of introns from precursor messenger RNA (pre-mRNA) and some noncoding
transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of …

Liquid–liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving
force underlying the formation of membrane-less organelles. Such biomolecular …

Abstract U1 snRNP (U1) functions in splicing introns and telescripting, which suppresses
premature cleavage and polyadenylation (PCPA). Using U1 inhibition in human cells, we …

Abstract The U12-dependent (minor) spliceosome excises a rare group of introns that are
characterized by a highly conserved 5′ splice site and branch point sequence. Several …