Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

X Han, A Alu, H Liu, Y Shi, X Wei, L Cai, Y Wei - Bioactive Materials, 2022 - Elsevier
Biotherapy has recently become a hotspot research topic with encouraging prospects in
various fields due to a wide range of treatments applications, as demonstrated in preclinical …

[HTML][HTML] A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury

Z Li, T Zhao, J Ding, H Gu, Q Wang, Y Wang, D Zhang… - Bioactive materials, 2023 - Elsevier
Spinal cord injury (SCI) is an overwhelming and incurable disabling event accompanied by
complicated inflammation-related pathological processes, such as excessive reactive …

Robust and multifunctional nanoparticles assembled from natural polyphenols and metformin for efficient spinal cord regeneration

T Yuan, T Wang, J Zhang, P Liu, J Xu, Z Gu, J Xu, Y Li - ACS nano, 2023 - ACS Publications
The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex
pathophysiological microenvironments at the injury site and the limited regenerative …

Fully biodegradable and long-term operational primary zinc batteries as power sources for electronic medicine

X Huang, H Hou, B Yu, J Bai, Y Guan, L Wang… - ACS …, 2023 - ACS Publications
Given the advantages of high energy density and easy deployment, biodegradable primary
battery systems remain as a promising power source to achieve bioresorbable electronic …

Schwann cell-derived exosomes and methylprednisolone composite patch for spinal cord injury repair

B Zhu, G Gu, J Ren, X Song, J Li, C Wang, W Zhang… - ACS …, 2023 - ACS Publications
Spinal cord injury (SCI) can cause permanent loss of sensory and motor function, and there
is no effective clinical treatment, to date. Due to the complex pathological process involved …

[HTML][HTML] A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair

B Yang, C Liang, D Chen, F Cheng, Y Zhang, S Wang… - Bioactive materials, 2022 - Elsevier
The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the
biological microenvironment by filling the injured cavity area and increasing neuronal …

Harnessing the therapeutic potential of extracellular vesicles for biomedical applications using multifunctional magnetic nanomaterials

L Yang, KD Patel, C Rathnam, R Thangam, Y Hou… - Small, 2022 - Wiley Online Library
Extracellular vesicles (eg, exosomes) carrying various biomolecules (eg, proteins, lipids,
and nucleic acids) have rapidly emerged as promising platforms for many biomedical …

Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury

H Suzuki, Y Imajo, M Funaba, H Ikeda… - International Journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological
deficit and social and financial burdens. It is currently being managed symptomatically, with …

Bioactive 2D nanomaterials for neural repair and regeneration

X He, Y Zhu, B Ma, X Xu, R Huang, L Cheng… - Advanced Drug Delivery …, 2022 - Elsevier
Biomaterials have provided promising strategies towards improving the functions of injured
tissues of the nervous system. Recently, 2D nanomaterials, such as graphene, layered …