The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Comparative analysis of primate genomes within a phylogenetic context is essential for
understanding the evolution of human genetic architecture and primate diversity. We present …

One of the great strengths of the mouse model is the wide array of genetic tools that have
been developed. Striking examples include methods for directed modification of the …

Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in
nature, but the mechanisms underlying the evolution of lifespan differences remain elusive …

Millions of human genomes and exomes have been sequenced, but their clinical
applications remain limited due to the difficulty of distinguishing disease-causing mutations …

Human life expectancy has increased over the past few centuries, and the incidence of
dementia in the older population is also projected to continue to rise. Neurodegenerative …

The common marmoset (Callithrix jacchus), a small New World primate, is receiving
substantial attention in the neuroscience and biomedical science fields because its …

Elucidation of the evolutionary history and interrelatedness of Plasmodium species that
infect humans has been hampered by a lack of genetic information for three human-infective …

There has been, and continues to be, a dramatic shift in the human population towards older
ages necessitating biomedical research aimed at better understanding the basic biology of …