The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …

The objective of this work is to present a review of computational tools and models for
pharmaceutical processes, specifically those for the continuous manufacture of solid dosage …

Manufacturing of powder-based products is a focus of increasing research in the recent
years. The main reason is the lack of predictive process models connecting process …

The pharmaceutical industry is under growing pressure to increase efficiency, both in
production and in process development. This paper discusses the central role of Process …

Continuous manufacturing has attracted increasing research attention in the pharmaceutical
industry within the last decade. Based on the extensive experimental studies, numerous …

Residence time distribution (RTD) models are essential to understand process dynamics
and support process monitoring and control in continuous manufacturing systems. RTD …

It is desirable for a pharmaceutical final dosage form to be manufactured through a quality
by design (QbD)-based approach rather than a quality by testing (QbT) approach. An …

Simulation-based optimization is a research area that is currently attracting a lot of attention
in many industrial applications, where expensive simulators are used to approximate …

Research emphases on extensive experimental studies and modeling efforts have been on
the rise for the development of accurate predictive models of pharmaceutical unit operations …

Reduced-order modeling (ROM) techniques are playing a very significant role in the recent
literature bridging the gap between computationally expensive simulators and their …