B-cell and T-cell epitopes in anti-factor VIII immune responses
KP Pratt, AR Thompson - Clinical reviews in allergy & immunology, 2009 - Springer
Adequate hemostasis is achieved for many hemophilia A patients by infusion of plasma-
derived or recombinant factor VIII (FVIII), but unfortunately, a significant subset of patients …
derived or recombinant factor VIII (FVIII), but unfortunately, a significant subset of patients …
Quantitation of anti–factor VIII antibodies in human plasma
J Krudysz-Amblo, B Parhami-Seren… - Blood, The Journal …, 2009 - ashpublications.org
The presence of antibodies (Abs) in hemophilia A patients can potentially influence the
therapeutic qualities of factor VIII (fVIII) administration. Much work has been focused on the …
therapeutic qualities of factor VIII (fVIII) administration. Much work has been focused on the …
A shift towards a T cell cytokine deficiency along with an anti-inflammatory/regulatory microenvironment may enable the synthesis of anti-FVIII inhibitors in …
DG Chaves, C Velloso-Rodrigues… - Clinical & …, 2010 - academic.oup.com
Despite the clinical relevance of anti-factor VIII (FVIII) antibodies (anti-FVIII inhibitors)
impairing haemostatic activity of haemophilia A (HA) patients, the immunological …
impairing haemostatic activity of haemophilia A (HA) patients, the immunological …
Desenvolvimento de inibidores do fator VIII na hemofilia A
DG Chaves, CV Rodrigues - Revista Brasileira de Hematologia e …, 2009 - SciELO Brasil
A hemofilia A é uma coagulopatia genética com herança recessiva ligada ao cromossomo X
que afeta 1-2 a cada 10 mil indivíduos do sexo masculino nascidos vivos. Estes indivíduos …
que afeta 1-2 a cada 10 mil indivíduos do sexo masculino nascidos vivos. Estes indivíduos …
Epitope specificity of anti-factor VIII antibodies from inhibitor positive acquired and congenital haemophilia A patients using synthetic peptides spanning A and C …
S Gharagozlou, RA Sharifian… - Thrombosis and …, 2009 - thieme-connect.com
Development of antibodies (Ab) that either block the function of coagulation factor VIII
(FVIII)(inhibitors) or clear it from circulation, seriously complicate the treatment of …
(FVIII)(inhibitors) or clear it from circulation, seriously complicate the treatment of …
Discontinuous epitopes on the C2 domain of coagulation Factor VIII mapped by computer‐designed synthetic peptides
A Lebreton, V Moreau, P Lapalud… - British journal of …, 2011 - Wiley Online Library
The occurrence of alloantibodies against Factor VIII (FVIII) is the main iatrogenic
complication in haemophilia A (HA). Anti‐FVIII autoantibodies may also spontaneously …
complication in haemophilia A (HA). Anti‐FVIII autoantibodies may also spontaneously …
Computer‐predicted peptides that mimic discontinuous epitopes on the A2 domain of factor VIII
A Lebreton, N Simon, V Moreau, V Demolombe… - …, 2015 - Wiley Online Library
Development of antibodies (Abs) against factor VIII (FVIII) is a severe complication of
haemophilia A treatment. Recent publications suggest that domain specificity of anti‐FVIII …
haemophilia A treatment. Recent publications suggest that domain specificity of anti‐FVIII …
Benchmarking the PEPOP methods for mimicking discontinuous epitopes
V Demolombe, AG de Brevern, F Molina, G Lavigne… - BMC …, 2019 - Springer
Background Computational methods provide approaches to identify epitopes in protein Ags
to help characterizing potential biomarkers identified by high-throughput genomic or …
to help characterizing potential biomarkers identified by high-throughput genomic or …
[HTML][HTML] In silico study of correlation between missense variations of F8 gene and inhibitor formation in severe Hemophilia A
M Fodil, F Zemani - Turkish Journal of Hematology, 2020 - ncbi.nlm.nih.gov
Objective: Deleterious substitutions of the F8 gene are responsible for causing hemophilia
A, which is an inherited bleeding disorder resulting from reduced or absent activity of the …
A, which is an inherited bleeding disorder resulting from reduced or absent activity of the …
Development of factor VIII inhibitors in hemophilia A
DG Chaves, CV Rodrigues - Revista Brasileira de Hematologia e …, 2009 - SciELO Brasil
A hemofilia A é uma coagulopatia genética com herança recessiva ligada ao cromossomo X
que afeta 1-2 a cada 10 mil indivíduos do sexo masculino nascidos vivos. Estes indivíduos …
que afeta 1-2 a cada 10 mil indivíduos do sexo masculino nascidos vivos. Estes indivíduos …