Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …

Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized by
diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend …

Several lines of investigation have helped clarify the role of GAP-43 (F1, B-50 or
neuromodulin) in regulating the growth state of axon terminals. In transgenic mice …

Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …

Gene replacement and pre-mRNA splicing modifier therapies represent breakthrough gene
targeting treatments for the neuromuscular disease spinal muscular atrophy (SMA), but …

Stroke is the second cause of death and more importantly first cause of disability in people
over 40 years of age. Current therapeutic management of ischemic stroke does not provide …

Introduction The level of the presynaptic protein growth‐associated protein 43 (GAP‐43) in
cerebrospinal fluid (CSF) has previously been shown to be increased in Alzheimer's disease …

For nerve cells to develop their highly polarized form, appropriate structural molecules must
be targeted to either axons or dendrites. This could be achieved by the synthesis of …

Intercellular communication among cancer cells and their microenvironment is crucial to
disease progression. The mechanisms by which communication occurs between distant …