Three-membered carbocycles are extremely important versatile building blocks for organic
chemistry. Their unique structural and electronic properties give rise to an array of very …

Nature produces a variety of different species, prokaryotes and eukaryotes. Among them,
fungi play a very important, but yet mostly unexplored role. Their widespread occurrence on …

In the last decade, the molecular chaperone HSP90 has emerged as an important target in
cancer therapeutics and has subsequently become the focus of several drug discovery and …

The construction of macrocycles by ring‐closing metathesis (RCM) is often used as the key
step in the synthesis of natural products containing large rings. This reaction is attractive …

The molecular chaperone Hsp90 (90 kDa heat-shock protein) is a remarkably versatile
protein involved in the stress response and in normal homoeostatic control mechanisms. It …

Natural products have been a rich source of agents of value in medicine. They have also
inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import …

Chaperones (stress proteins) are essential proteins to help the formation and maintenance
of the proper conformation of other proteins and to promote cell survival after a large variety …

The molecular chaperone heat shock protein 90 (HSP90) has emerged as an exciting
molecular target for cancer therapy. It operates as part of a multichaperone complex and is …

The Hsp90 chaperone is a master regulator of the stability and activity of multiple
oncoproteins such as Her2, Akt, Bcr-Abl, c-Kit, EGFR and mutant BRAF. The promise of …

The 90 kDa heat shock proteins (Hsp90) are responsible for the conformational maturation
of nascent polypeptides and the renaturation of denatured proteins. In transformed cells …