Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

Disturbances of sleep are typical for most depressed patients and belong to the core
symptoms of the disorder. Polysomnographic sleep research has demonstrated that besides …

For many years, researchers have suggested that abnormalities in circadian rhythms may
underlie the development of mood disorders such as bipolar disorder (BPD), major …

It has long been appreciated that sleep problems are common among those with psychiatric
disorders. The prevailing view has been that sleep problems are generally symptoms of the …

Delirium is the most common complication found in the general hospital setting. Yet, we
know relatively little about its actual pathophysiology. This article contains a summary of …

Insomnia is a pervasive problem for many patients suffering from medical and psychiatric
conditions. Even when the comorbid disorders are successfully treated, insomnia often fails …

Delirium is a neurobehavioral syndrome caused by the transient disruption of normal
neuronal activity secondary to systemic disturbances. It is also the most common psychiatric …

Manipulations of the sleep-wake cycle, whether of duration (total or partial sleep deprivation
[SD]) or timing (partial SD, phase advance), have profound and rapid effects on depressed …

The cyclic nature of depressive illness, the diurnal variations in its symptomatology and the
existence of disturbed sleep–wake and core body temperature rhythms, all suggest that …

Currently available antidepressants used to treat major depressive disorder (MDD)
unfortunately often take weeks to months to achieve their full effects, commonly resulting in …