Viruses have evolved complex and dynamic interactions with their host cell. In recent years
we have gained insight into the expanding roles for host lipids in the virus life cycle. In …

Covering: up to April 2014 The development of drugs with broad-spectrum antiviral activities
is a long pursued goal in drug discovery. It has been shown that blocking co-opted host …

HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered
membrane microdomains. The size and stability of membrane microdomains is regulated by …

Gag, the primary structural protein of HIV-1, is recruited to the plasma membrane for virus
assembly by its matrix (MA) domain. Gag is subsequently cleaved into its component …

Although HIV-1 Gag is known to drive viral assembly and budding, the precise mechanisms
by which the lipid composition of the plasma membrane is remodeled during assembly are …

Retroviruses acquire a lipid envelope during budding from the membrane of their hosts.
Therefore, the composition of this envelope can provide important information about the …

Membrane binding of Gag, a crucial step in HIV-1 assembly, is facilitated by bipartite signals
within the matrix (MA) domain: N-terminal myristoyl moiety and the highly basic region …

Recent work has illuminated three critical aspects of the cell biology of HIV-1 particle
genesis. First, we have come to understand which cellular membranes are selected as …

As a member of the retrovirus family, HIV-1 packages its RNA genome into particles and
replicates through a DNA intermediate that integrates into the host cellular genome. The …

Virus transmission can occur either by a cell-free mode through the extracellular space or by
cell-to-cell transmission involving direct cell-to-cell contact. The factors that determine …