[HTML][HTML] Homologous recombination and the repair of DNA double-strand breaks
WD Wright, SS Shah, WD Heyer - Journal of Biological Chemistry, 2018 - ASBMB
Homologous recombination enables the cell to access and copy intact DNA sequence
information in trans, particularly to repair DNA damage affecting both strands of the double …
information in trans, particularly to repair DNA damage affecting both strands of the double …
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
3D structures of individual mammalian genomes studied by single-cell Hi-C
The folding of genomic DNA from the beads-on-a-string-like structure of nucleosomes into
higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D …
higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D …
Target gene-independent functions of MYC oncoproteins
Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …
body of evidence indicates that MYC proteins are transcription factors, studying their function …
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic
nuclear processes and trigger DNA damage, genome instability, and cell killing. By different …
nuclear processes and trigger DNA damage, genome instability, and cell killing. By different …
Detection of genomic G-quadruplexes in living cells using a small artificial protein
K Zheng, J Zhang, Y He, J Gong, C Wen… - Nucleic acids …, 2020 - academic.oup.com
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …
in essential physiological and pathological processes and serve as important drug targets …
[HTML][HTML] Anthracyclines as topoisomerase II poisons: from early studies to new perspectives
J Marinello, M Delcuratolo, G Capranico - International journal of …, 2018 - mdpi.com
Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by
stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to …
stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to …
Transcription-mediated replication hindrance: a major driver of genome instability
B Gómez-González, A Aguilera - Genes & development, 2019 - genesdev.cshlp.org
Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …
DNA structure and function
A Travers, G Muskhelishvili - The FEBS journal, 2015 - Wiley Online Library
The proposal of a double‐helical structure for DNA over 60 years ago provided an eminently
satisfying explanation for the heritability of genetic information. But why is DNA, and not …
satisfying explanation for the heritability of genetic information. But why is DNA, and not …
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …