[HTML][HTML] Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
[HTML][HTML] Association between insulin resistance and the development of cardiovascular disease
V Ormazabal, S Nair, O Elfeky, C Aguayo… - Cardiovascular …, 2018 - Springer
For many years, cardiovascular disease (CVD) has been the leading cause of death around
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …
[HTML][HTML] Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases
R Ghemrawi, M Khair - International journal of molecular sciences, 2020 - mdpi.com
The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …
[HTML][HTML] Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response
Y Lin, M Jiang, W Chen, T Zhao, Y Wei - Biomedicine & Pharmacotherapy, 2019 - Elsevier
The endoplasmic reticulum (ER) acts as a moving organelle with many important cellular
functions. As the ER lacks sufficient nutrients under pathological conditions leading to …
functions. As the ER lacks sufficient nutrients under pathological conditions leading to …
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
G Jia, VG DeMarco, JR Sowers - Nature Reviews Endocrinology, 2016 - nature.com
Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote
the development of a specific form of cardiomyopathy that is independent of coronary artery …
the development of a specific form of cardiomyopathy that is independent of coronary artery …
[HTML][HTML] Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis
MJ Piao, MJ Ahn, KA Kang, YS Ryu, YJ Hyun… - Archives of …, 2018 - Springer
The skin is the largest organ of the human body and the one mostly exposed to outdoor
contaminants. To evaluate the biological mechanisms underlying skin damage caused by …
contaminants. To evaluate the biological mechanisms underlying skin damage caused by …
Plasma-activated medium induces A549 cell injury via a spiral apoptotic cascade involving the mitochondrial–nuclear network
T Adachi, H Tanaka, S Nonomura, H Hara… - Free Radical Biology …, 2015 - Elsevier
Plasma medicine is a rapidly expanding new field of interdisciplinary research that
combines physics, chemistry, biology, and medicine. Nonthermal atmospheric pressure …
combines physics, chemistry, biology, and medicine. Nonthermal atmospheric pressure …
Regulation of autophagy by canonical and non-canonical ER stress responses
Cancer cells encounter numerous stresses that pose a threat to their survival. Tumor
microenviroment stresses that perturb protein homeostasis can produce endoplasmic …
microenviroment stresses that perturb protein homeostasis can produce endoplasmic …
[HTML][HTML] Hypoxia and selective autophagy in cancer development and therapy
Low oxygen availability, a condition known as hypoxia, is a common feature of various
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …
[HTML][HTML] Endoplasmic reticulum stress and the unfolded protein response in cerebral ischemia/reperfusion injury
Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of
blood flow in a certain part of the brain, leading to serious disability and death. At present …
blood flow in a certain part of the brain, leading to serious disability and death. At present …