The Caenorhabditis elegans germ line provides an exceptional model for analysis of the
molecular controls governing stem cell maintenance, the cell cycle transition from mitosis to …

Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …

Prior to fertilization, oocytes undergo meiotic maturation (cell cycle progression) and
ovulation (expulsion from the ovary). To begin the study of these processes …

Genetic and embryological experiments have established the Caenorhabditis elegans adult
hermaphrodite gonad as a paradigm for studying the control of germline development and …

Cell proliferation must be coordinated with cell fate specification during development, yet
interactions among pathways that control these two critical aspects of development are not …

Sexual reproduction of multicellular organisms depends critically on the coordinate
development of the germ line and somatic gonad, a process known as gonadogenesis …

The C. elegans germ line proliferates from one primordial germ cell (PGC) set aside in the
early embryo to over a thousand cells in the adult. Most germline proliferation is controlled …

Germ cells normally differentiate in the context of encapsulating somatic cells. However, the
mechanisms that set up the special relationship between germ cells and somatic support …

The C. elegans defecation cycle is characterized by the contraction of three distinct sets of
muscles every 50 s. Our data indicate that this cycle is regulated by periodic calcium release …

The raison d'etre of the germline is to produce oocytes and sperm that pass genetic material
and cytoplasmic constituents to the next generation. To achieve this goal, many …