Artificial intelligence in histopathology: enhancing cancer research and clinical oncology

A Shmatko, N Ghaffari Laleh, M Gerstung, JN Kather - Nature cancer, 2022 - nature.com
Artificial intelligence (AI) methods have multiplied our capabilities to extract quantitative
information from digital histopathology images. AI is expected to reduce workload for human …

[HTML][HTML] Digital pathology and artificial intelligence in translational medicine and clinical practice

V Baxi, R Edwards, M Montalto, S Saha - Modern Pathology, 2022 - Elsevier
Traditional pathology approaches have played an integral role in the delivery of diagnosis,
semi-quantitative or qualitative assessment of protein expression, and classification of …

Artificial intelligence to identify genetic alterations in conventional histopathology

D Cifci, S Foersch, JN Kather - The Journal of Pathology, 2022 - Wiley Online Library
Precision oncology relies on the identification of targetable molecular alterations in tumor
tissues. In many tumor types, a limited set of molecular tests is currently part of standard …

[HTML][HTML] Predictive uncertainty estimation for out-of-distribution detection in digital pathology

J Linmans, S Elfwing, J van der Laak, G Litjens - Medical Image Analysis, 2023 - Elsevier
Abstract Machine learning model deployment in clinical practice demands real-time risk
assessment to identify situations in which the model is uncertain. Once deployed, models …

[HTML][HTML] Artificial intelligence for detection of microsatellite instability in colorectal cancer—a multicentric analysis of a pre-screening tool for clinical application

A Echle, NG Laleh, P Quirke, HI Grabsch, HS Muti… - ESMO open, 2022 - Elsevier
Background Microsatellite instability (MSI)/mismatch repair deficiency (dMMR) is a key
genetic feature which should be tested in every patient with colorectal cancer (CRC) …

The state of the art for artificial intelligence in lung digital pathology

VS Viswanathan, P Toro, G Corredor… - The Journal of …, 2022 - Wiley Online Library
Lung diseases carry a significant burden of morbidity and mortality worldwide. The advent of
digital pathology (DP) and an increase in computational power have led to the development …

A generalizable and robust deep learning algorithm for mitosis detection in multicenter breast histopathological images

X Wang, J Zhang, S Yang, J Xiang, F Luo, M Wang… - Medical image …, 2023 - Elsevier
Mitosis counting of biopsies is an important biomarker for breast cancer patients, which
supports disease prognostication and treatment planning. Developing a robust mitotic cell …

Overcoming the challenges to implementation of artificial intelligence in pathology

JS Reis-Filho, JN Kather - JNCI: Journal of the National Cancer …, 2023 - academic.oup.com
Pathologists worldwide are facing remarkable challenges with increasing workloads and
lack of time to provide consistently high-quality patient care. The application of artificial …

Facts and hopes on the use of artificial intelligence for predictive immunotherapy biomarkers in cancer

N Ghaffari Laleh, M Ligero, R Perez-Lopez… - Clinical Cancer …, 2023 - AACR
Immunotherapy by immune checkpoint inhibitors has become a standard treatment strategy
for many types of solid tumors. However, the majority of patients with cancer will not …

Scaling self-supervised learning for histopathology with masked image modeling

A Filiot, R Ghermi, A Olivier, P Jacob, L Fidon… - medRxiv, 2023 - medrxiv.org
Computational pathology is revolutionizing the field of pathology by integrating advanced
computer vision and machine learning technologies into diagnostic workflows. It offers …