Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In …
SM Hefny, TF El-Moselhy, N El-Din… - Journal of Medicinal …, 2024 - ACS Publications
A dual-targeting approach is predicted to yield better cancer therapy outcomes.
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic …
Schiff bases tethered with sulfonamide functionality (6a-l) are reported as potential
anticancer agents and apoptotic inducers. The anti-proliferative activities of the tested Schiff …
anticancer agents and apoptotic inducers. The anti-proliferative activities of the tested Schiff …
Identification of 3‐(5‐cyano‐6‐oxo‐pyridin‐2‐yl) benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity
MA Shaldam, AF Khalil, H Almahli… - Archiv der …, 2024 - Wiley Online Library
Abstract New 5‐cyano‐6‐oxo‐pyridine‐based sulfonamides (6a–m and 8a–d) were
designed and synthesized to potentially inhibit both the epidermal growth factor receptor …
designed and synthesized to potentially inhibit both the epidermal growth factor receptor …
Exploring the binding mechanism of Pomalidomide drug with CT-DNA: Insights from multi-spectroscopic, molecular docking and simulation studies
K Pavithra, RD Priyadharshini, KN Vennila… - Journal of Molecular …, 2024 - Elsevier
Exploration of the interaction of a thalidomide analogue immunomodulatory and anti-
angiogenic drug pomalidomide (POD) with calf thymus DNA (CT-DNA) was carried out …
angiogenic drug pomalidomide (POD) with calf thymus DNA (CT-DNA) was carried out …
Study of the binding interaction of salmon sperm DNA with nintedanib, a tyrosine kinase inhibitor using multi-spectroscopic, thermodynamic, and in silico approaches
The study of the intermolecular binding interaction of small molecules with DNA can guide
the rational drug design with greater efficacy and improved or more selective activity. In the …
the rational drug design with greater efficacy and improved or more selective activity. In the …
Emphasized DFT, DNA binding, and electrochemical studies of hybrid 1, 3, 4-thiadiazole-linked chalcone confined via a sulfur bridge
We have investigated the photophysical properties of chalcone derivatives by UV-visible
absorption spectra. The HOMO–LUMO energies were calculated. Electrochemical …
absorption spectra. The HOMO–LUMO energies were calculated. Electrochemical …