In biocatalysis, structural knowledge regarding an enzyme and its substrate interactions
complements and guides experimental investigations. Structural knowledge regarding an …

TRPM4 is a calcium-activated, phosphatidylinositol-4, 5-bisphosphate (PtdIns (4, 5) P2)-
modulated, non-selective cation channel that belongs to the family of melastatin-related …

Carboxylic ester hydrolases (CEHs), which catalyze the hydrolysis of carboxylic esters to
produce alcohol and acid, are identified in three domains of life. In the Protein Data Bank …

Thioesterases are present in all living cells and perform a wide range of important biological
functions by catalysing the cleavage of thioester bonds present in a diverse array of cellular …

Modern rational drug design not only deals with the search for ligands binding to interesting
and promising validated targets but also aims to identify the function and ligands of yet …

Herein, we present a novel esterase enzyme, Ade1, isolated from a metagenomic library of
Amazonian dark earths soils, demonstrating its broad substrate promiscuity by hydrolyzing …

The stringent response alarmones pppGpp and ppGpp are essential for rapid adaption of
bacterial physiology to changes in the environment. In Escherichia coli, the nucleosidase …

Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant
nontuberculous mycobacteria that has emerged as a growing threat to individuals with cystic …

Hydride transfer plays a crucial role in a wide range of biological systems. However, its
mode of action (concerted or stepwise) is still under debate. Light‐dependent NADPH …

In mycobacteria, σA is the primary sigma factor. This essential protein binds to RNA
polymerase (RNAP) and mediates transcription initiation of housekeeping genes. Our …