BDNF signaling in context: From synaptic regulation to psychiatric disorders

CS Wang, ET Kavalali, LM Monteggia - Cell, 2022 - cell.com
Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy

M Notaras, R Hill, M van den Buuse - Molecular psychiatry, 2015 - nature.com
Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the developing and adult brain. A single-nucleotide …

Early versus late onset obsessive–compulsive disorder: evidence for distinct subtypes

S Taylor - Clinical psychology review, 2011 - Elsevier
The distinction between early versus late onset is important for understanding many different
kinds of disorders. In an effort to identify etiologically homogeneous subtypes of obsessive …

Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis

S Suliman, SMJ Hemmings, S Seedat - Frontiers in integrative …, 2013 - frontiersin.org
Background: Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that is involved in
the synaptic plasticity and survival of neurons. BDNF is believed to be involved in the …

Impacts of Neanderthal-introgressed sequences on the landscape of human gene expression

RC McCoy, J Wakefield, JM Akey - Cell, 2017 - cell.com
Regulatory variation influencing gene expression is a key contributor to phenotypic diversity,
both within and between species. Unfortunately, RNA degrades too rapidly to be recovered …

Population genetic study of the brain-derived neurotrophic factor (BDNF) gene

TL Petryshen, PC Sabeti, KA Aldinger, B Fry… - Molecular …, 2010 - nature.com
Genetic variants in the brain-derived neurotrophic factor (BDNF) gene, predominantly the
functional Val66Met polymorphism, have been associated with risk of bipolar disorder and …

Gender differences in obsessive-compulsive disorder: a literature review

MA Mathis, P Alvarenga, G Funaro… - Brazilian Journal of …, 2011 - SciELO Brasil
INTRODUCTION: Obsessive-compulsive disorder (OCD) is a heterogeneous condition, in
which subtypes have been proposed. Previous studies suggested that gender plays a …

Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in …

C Dong, ML Wong, J Licinio - Molecular psychiatry, 2009 - nature.com
We studied seven genes that reflect events relevant to antidepressant action at four
sequential levels:(1) entry into the brain,(2) binding to monoaminergic transporters, and (3) …

Animal models of obsessive–compulsive disorder: utility and limitations

P Alonso, C López-Solà, E Real… - Neuropsychiatric …, 2015 - Taylor & Francis
Obsessive–compulsive disorder (OCD) is a disabling and common neuropsychiatric
condition of poorly known etiology. Many attempts have been made in the last few years to …

Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism

CT Correia, AM Coutinho, AF Sequeira… - Genes, Brain and …, 2010 - Wiley Online Library
The brain‐derived neurotrophic factor (BDNF), a neurotrophin fundamental for brain
development and function, has previously been implicated in autism. In this study, the levels …