Oxidative stress resulting from excessive free-radical release is likely implicated in the
initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing …

The brain is an organ predisposed to oxidative/nitrosative stress. This is especially true in
the case of aging as well as several neurodegenerative diseases. Under such …

It is thought that autism could result from an interaction between genetic and environmental
factors with oxidative stress as a potential mechanism linking the two. One genetic factor …

Epileptic patients exhibited variably altered status of trace elements, electrolytes, and free
radical scavenging enzyme activities. We investigated the effect of epilepsy and long-term …

Epilepsy is considered one of the most common neurological disorders. The focus of this
review is the acquired form of epilepsy, with the development process consisting of three …

A single dose of valproic acid (VPA), which is a widely used antiepileptic drug, is associated
with oxidative stress in rats, as recently demonstrated by elevated levels of 15-F2t …

Epilepsy is known as one of the most frequent neurological diseases, characterized by an
enduring predisposition to generate epileptic seizures. Oxidative stress is believed to …

Emerging evidence shows that redox‐sensitive signal transduction pathways are critical for
developmental processes, including proliferation, differentiation, and apoptosis. As a …

Valproic acid (2-n-propylpentanoic acid; VPA) has several therapeutic indications, but it is
used primarily as an anticonvulsant. VPA is a relatively safe drug, but its use is associated …

Oxidative stress has been associated with valproic acid (VPA) treatment, and mitochondrial
dysfunction has been implicated in the pathogenesis of VPA-idiosyncratic hepatotoxicity …