Thrombospondins: a role in cardiovascular disease
DA Chistiakov, AA Melnichenko… - International journal of …, 2017 - mdpi.com
Thrombospondins (TSPs) represent extracellular matrix (ECM) proteins belonging to the
TSP family that comprises five members. All TSPs have a complex multidomain structure that …
TSP family that comprises five members. All TSPs have a complex multidomain structure that …
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …
induced mediators of cellular attachment dynamics and extracellular matrix protein …
Defining the adult neural stem cell niche proteome identifies key regulators of adult neurogenesis
J Kjell, J Fischer-Sternjak, AJ Thompson, C Friess… - Cell stem cell, 2020 - cell.com
The mammalian brain contains few niches for neural stem cells (NSCs) capable of
generating new neurons, whereas other regions are primarily gliogenic. Here we leverage …
generating new neurons, whereas other regions are primarily gliogenic. Here we leverage …
Cardiac muscle membrane stabilization in myocardial reperfusion injury
The phospholipid bilayer membrane that surrounds each cell in the body represents the first
and last line of defense for preserving overall cell viability. In several forms of cardiac and …
and last line of defense for preserving overall cell viability. In several forms of cardiac and …
Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy
TA Baldwin, JP Teuber, Y Kuwabara… - Journal of Biological …, 2023 - ASBMB
S-palmitoylation is a reversible lipid modification catalyzed by 23 S-acyltransferases with a
conserved zinc finger aspartate-histidine-histidine-cysteine (zDHHC) domain that facilitates …
conserved zinc finger aspartate-histidine-histidine-cysteine (zDHHC) domain that facilitates …
Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo
Lack of type VII collagen (C7) disrupts cellular proteostasis yet the mechanism remains
undescribed. By studying the relationship between C7 and the extracellular matrix (ECM) …
undescribed. By studying the relationship between C7 and the extracellular matrix (ECM) …
GRP78 interacting partner Bag5 responds to ER stress and protects cardiomyocytes from ER stress‐induced apoptosis
Bag5 is a member of the BAG family of molecular chaperone regulators and is unusual in
that it consists of five BAG domains, which function as modulators of chaperone activity. Bag …
that it consists of five BAG domains, which function as modulators of chaperone activity. Bag …
zDHHC9 regulates cardiomyocyte Rab3a activity and atrial natriuretic peptide secretion through palmitoylation of Rab3gap1
K Essandoh, A Subramani, OA Ferro, JP Teuber… - Basic to Translational …, 2023 - jacc.org
Production and release of natriuretic peptides by the stressed heart reduce cardiac workload
by promoting vasodilation, natriuresis, and diuresis, which has been leveraged in the recent …
by promoting vasodilation, natriuresis, and diuresis, which has been leveraged in the recent …
Thrombospondin expression in myofibers stabilizes muscle membranes
D Vanhoutte, TG Schips, JQ Kwong, J Davis… - Elife, 2016 - elifesciences.org
Skeletal muscle is highly sensitive to mutations in genes that participate in membrane
stability and cellular attachment, which often leads to muscular dystrophy. Here we show …
stability and cellular attachment, which often leads to muscular dystrophy. Here we show …
Effects of thrombospondin-4 on pro-inflammatory phenotype differentiation and apoptosis in macrophages
Abstract Thrombospondin-4 (TSP-4) attracted renewed attention recently as a result of
assignment of new functions to this matricellular protein in cardiovascular, muscular, and …
assignment of new functions to this matricellular protein in cardiovascular, muscular, and …