Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …

Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …

Abstract Alveolar epithelial type 1 (AT1) cells are necessary to transfer oxygen and carbon
dioxide between the blood and air. Alveolar epithelial type 2 (AT2) cells serve as a partially …

Foods high in carbohydrates are an important part of a healthy diet, since they provide the
body with glucose to support bodily functions and physical activity. However, the abusive …

Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Viruses hijack host cell metabolism to acquire the building blocks required for replication.
Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential …

Metastasis is an inefficient process in which the vast majority of cancer cells are fated to die,
partly because they experience oxidative stress. Metastasizing cancer cells migrate through …