Binding and displacement study of gentamicin, 5-fluorouracil, oxytetracycline and rolitetracycline with (BSA: Drug2) complex using spectroscopic and calorimetric …

M Thorve, N Kishore - International Journal of Biological Macromolecules, 2024 - Elsevier
Understanding of energetics of interactions between drug and protein is essential in
pharmacokinetics and pharmacodynamics study. The binding affinity (K) helps in …

Aflatoxin B1 Induced Structural and Conformational Changes in Bovine Serum Albumin: A Multispectroscopic and Circular Dichroism-Based Study

MA Qureshi, S Javed - ACS omega, 2021 - ACS Publications
Aflatoxin B1 (AFB1) is a mutagen that has been categorized as a group 1 human carcinogen
by the International Agency for Research on Cancer. It is produced as a secondary …

Bovine Serum Albumin as a Platform for Designing Biologically Active Nanocarriers—Experimental and Computational Studies

O Adamczyk, M Szota, K Rakowski… - International Journal of …, 2023 - mdpi.com
Due to the specificity of their structure, protein systems are adapted to carry various ligands.
The structure of many proteins potentially allows for two types of immobilization of a …

Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis

K Dubey, BG Anand, DS Shekhawat, K Kar - Scientific reports, 2017 - nature.com
Eugenol has attracted considerable attention because of its potential for many
pharmaceutical applications including anti-inflammatory, anti-tumorigenic and anti-oxidant …

Dendrimer Platforms for Targeted Doxorubicin Delivery—Physicochemical Properties in Context of Biological Responses

M Szota, U Szwedowicz, N Rembialkowska… - International Journal of …, 2024 - mdpi.com
The unique structure of G4. 0 PAMAM dendrimers allows a drug to be enclosed in internal
spaces or immobilized on the surface. In the conducted research, the conditions for the …

Competitive binding of (−)-epigallocatechin-3-gallate and 5-fluorouracil to human serum albumin: A fluorescence and circular dichroism study

L Yuan, M Liu, G Liu, D Li, Z Wang, B Wang… - … Acta Part A: Molecular …, 2017 - Elsevier
Combination therapy with more than one therapeutic agent can improve therapeutic
efficiency and decrease drug resistance. In this study, the interactions of human serum …

Nano-bio interaction between blood plasma proteins and water-soluble silicon quantum dots with enabled cellular uptake and minimal cytotoxicity

S Chinnathambi, N Hanagata, T Yamazaki… - Nanomaterials, 2020 - mdpi.com
A better understanding of the compatibility of water-soluble semiconductor quantum dots
(QDs) upon contact with the bloodstream is important for biological applications, including …

Insights into the binding of thiosemicarbazone derivatives with human serum albumin: spectroscopy and molecular modelling studies

S Karthikeyan, G Bharanidharan… - Journal of …, 2016 - Taylor & Francis
4-[(1 Z)-1-(2-carbamothioylhydrazinylidene) ethyl] phenyl acetate [Ace semi], 4-[(1 Z)-1-(2-
carbamothioylhydrazinylidene) ethyl] phenyl propanoate [Pro semi] from the family of …

Synergistic delivery of 5-fluorouracil and curcumin using human serum albumin-coated iron oxide nanoparticles by folic acid targeting

CG Hiremath, MY Kariduraganavar… - Progress in …, 2018 - Springer
Human serum albumin is the most abundant protein in plasma with the ability to bind to a
variety of drug molecules. Magnetic nanoparticles are being extensively used in drug …

Calorimetric and spectroscopic studies on the competitive behavior between (−)-epigallocatechin-3-gallate and 5-fluorouracil with human serum albumin

L Yuan, M Liu, B Sun, J Liu, X Wei, Z Wang… - Journal of Molecular …, 2017 - Elsevier
The combination of several drugs is often necessary, especially during long-term therapy.
Drug-protein interaction has attracted a great deal of research interest because only the free …