[HTML][HTML] Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation

D Hos, M Matthaei, F Bock, K Maruyama… - Progress in retinal and …, 2019 - Elsevier
In the past decade, novel lamellar keratoplasty techniques such as Deep Anterior Lamellar
Keratoplasty (DALK) for anterior keratoplasty and Descemet stripping automated endothelial …

The novel role of lymphatic vessels in the pathogenesis of ocular diseases

T Clahsen, K Hadrian, M Notara, SL Schlereth… - Progress in Retinal and …, 2023 - Elsevier
Historically, the eye has been considered as an organ free of lymphatic vessels. In recent
years, however, it became evident, that lymphatic vessels or lymphatic-like vessels …

Macrophage-mediated tissue vascularization: similarities and differences between cornea and skin

K Hadrian, S Willenborg, F Bock, C Cursiefen… - Frontiers in …, 2021 - frontiersin.org
Macrophages are critical mediators of tissue vascularization both in health and disease. In
multiple tissues, macrophages have been identified as important regulators of both blood …

[HTML][HTML] Different innate immune responses in BALB/c and C57BL/6 strains following corneal transplantation

T Bleul, X Zhuang, A Hildebrand, C Lange… - Journal of Innate …, 2021 - karger.com
Purpose: To investigate immunological differences and the role of CD38+/F4/80+ M1
macrophages in C57BL/6J-and BALB/c-recipient mouse corneal transplantation models …

Lymphangiogenesis guidance mechanisms and therapeutic implications in pathological states of the cornea

M Patnam, SR Dommaraju, F Masood, P Herbst… - Cells, 2023 - mdpi.com
Corneal lymphangiogenesis is one component of the neovascularization observed in
several inflammatory pathologies of the cornea including dry eye disease and corneal graft …

Lymphatic trafficking in the eye: modulation of lymphatic trafficking to promote corneal transplant survival

Y Hou, F Bock, D Hos, C Cursiefen - Cells, 2021 - mdpi.com
(Lymph) angiogenesis into the cornea prior to and after corneal transplantation is a critical
risk factor for allograft rejection. Lymphatic vessels even more than blood vessels seem …

Cystathionine β-synthase as novel endogenous regulator of lymphangiogenesis via modulating VEGF receptor 2 and 3

N Hatami, C Büttner, F Bock, S Simfors… - Communications …, 2022 - nature.com
Lymphangiogenesis is a key player in several diseases such as tumor metastasis, obesity,
and graft rejection. Endogenous regulation of lymphangiogenesis is only partly understood …

Treatment with melatonin after corneal graft attenuates rejection

Z Zhu, R Peng, H Shen, L Zhong, S Song… - Frontiers in …, 2021 - frontiersin.org
Background: Immunologic graft rejection is the main complication of corneal transplants.
This study aimed to investigate the effect of melatonin (MT) on the rejection of corneal …

Role of endogenous regulators of hem-and lymphangiogenesis in corneal transplantation

T Clahsen, C Büttner, N Hatami, A Reis… - Journal of Clinical …, 2020 - mdpi.com
Under normal conditions, the cornea, being the transparent “windscreen” of the eye, is free
of both blood and lymphatic vessels. However, various diseases of the eye, like infections …

Immunomodulatory strategies targeting dendritic cells to improve corneal graft survival

A Schoenberg, M Hamdorf, F Bock - Journal of Clinical Medicine, 2020 - mdpi.com
Even though the cornea is regarded as an immune-privileged tissue, transplantation always
comes with the risk of rejection due to mismatches between donor and recipient. It is …