Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Glial tumors are one of the most common lesions of the central nervous system. Despite the
implementation of appropriate treatment, the prognosis is not successful. As shown in the …

Some of the side and beneficial effects of antiepileptic drugs (AEDs) are mediated via the
influence on mitochondria. This is of particular importance in patients requiring AED …

Introduction: Epilepsy is a frequent CNS manifestation of mitochondrial disorders (MIDs). At
present, patients with MID-related epilepsy are largely treated in the same way as any other …

Mitochondrial toxicity has been shown to contribute to a variety of organ toxicities such as
liver, cardiac, and kidney. In the past decades, two high-throughput applicable screening …

Several commonly used medications impair mitochondrial function resulting in adverse
effects or toxicities. Drug induced mitochondrial dysfunction may be a consequence of …

Mitochondrial impairment has been associated with the development of insulin resistance,
the hallmark of type 2 diabetes mellitus (T2DM). However, the relationship between …

Abstract Objectives Antiepileptic drugs (AEDs) exhibit adverse and beneficial effects on
mitochondria, which have a strong impact on the treatment of patients with a mitochondrial …

Allogeneic hematopoietic SCT (HSCT) has been proposed as a treatment for patients with
mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). HSCT has been …

The mitochondrial respiratory chain (MRC) and ATP synthase (complex V) play an essential
role in cellular energy production by the process of oxidative phosphorylation. In addition to …