Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

ME Bahar, HJ Kim, DR Kim - Signal transduction and targeted therapy, 2023 - nature.com
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

[HTML][HTML] An emerging focus on lipids in extracellular vesicles

T Skotland, K Sagini, K Sandvig, A Llorente - Advanced drug delivery …, 2020 - Elsevier
Extracellular vesicles contain a lipid bilayer membrane that protects the encapsulated
material, such as proteins, nucleic acids, lipids and metabolites, from the extracellular …

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

M Mauthe, I Orhon, C Rocchi, X Zhou, M Luhr… - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …

Mechanism and medical implications of mammalian autophagy

I Dikic, Z Elazar - Nature reviews Molecular cell biology, 2018 - nature.com
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

JM Mulcahy Levy, A Thorburn - Cell Death & Differentiation, 2020 - nature.com
Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting
in basal or stress-induced turnover of cell components that provide energy and …

Targeting autophagy in cancer

JMM Levy, CG Towers, A Thorburn - Nature Reviews Cancer, 2017 - nature.com
Autophagy is a mechanism by which cellular material is delivered to lysosomes for
degradation, leading to the basal turnover of cell components and providing energy and …

PI3K isoforms in cell signalling and vesicle trafficking

B Bilanges, Y Posor, B Vanhaesebroeck - Nature reviews Molecular …, 2019 - nature.com
PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

L Galluzzi, JM Bravo-San Pedro, B Levine… - Nature reviews Drug …, 2017 - nature.com
Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …

Autophagy: The spotlight for cellular stress responses

P Ravanan, IF Srikumar, P Talwar - Life sciences, 2017 - Elsevier
Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

Targeting autophagy in disease: established and new strategies

M Kocak, S Ezazi Erdi, G Jorba, I Maestro, J Farrés… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …