Cognitive and behavioural flexibility: neural mechanisms and clinical considerations

LQ Uddin - Nature Reviews Neuroscience, 2021 - nature.com
Cognitive and behavioural flexibility permit the appropriate adjustment of thoughts and
behaviours in response to changing environmental demands. Brain mechanisms enabling …

The autism advantage at work: A critical and systematic review of current evidence

SM Bury, D Hedley, M Uljarević, E Gal - Research in Developmental …, 2020 - Elsevier
Background Despite difficulties entering the workforce, people on the autism spectrum are
often successful. Furthermore, they are suggested to bring unique abilities (eg, attention to …

Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder

AM Buch, PE Vértes, J Seidlitz, SH Kim… - Nature …, 2023 - nature.com
The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent …

Neural mechanisms underlying repetitive behaviors in rodent models of autism spectrum disorders

T Gandhi, CC Lee - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

[HTML][HTML] Synaptic genes and neurodevelopmental disorders: From molecular mechanisms to developmental strategies of behavioral testing

C Michetti, A Falace, F Benfenati, A Fassio - Neurobiology of Disease, 2022 - Elsevier
Synaptopathies are a class of neurodevelopmental disorders caused by modification in
genes coding for synaptic proteins. These proteins oversee the process of …

Repetitive restricted behaviors in autism spectrum disorder: From mechanism to development of therapeutics

J Tian, X Gao, L Yang - Frontiers in neuroscience, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by deficits in social communication, social interaction, and repetitive restricted behaviors …

[HTML][HTML] Drug development for autism spectrum disorder (ASD): progress, challenges, and future directions

JT McCracken, E Anagnostou, C Arango… - European …, 2021 - Elsevier
In 2017, facing lack of progress and failures encountered in targeted drug development for
Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM …

Developmental cascades between insistence on sameness behaviour and anxiety symptoms in autism spectrum disorder

DA Baribeau, SN Vigod, E Pullenayegum… - European Child & …, 2023 - Springer
Autistic children experience high rates of anxiety. Insistence on sameness behaviour (IS) is
a core feature of autism that appears correlated with anxiety severity. The objective of this …

Arriving at the empirically based conceptualization of restricted and repetitive behaviors: A systematic review and meta-analytic examination of factor analyses

M Uljarević, EK Spackman, AJO Whitehouse… - Clinical Psychology …, 2023 - Elsevier
An empirically based understanding of the factor structure of the restricted and repetitive
behaviors (RRB) domain is a prerequisite for interpreting studies attempting to understand …

Aberrant dynamics of cognitive control and motor circuits predict distinct restricted and repetitive behaviors in children with autism

K Supekar, S Ryali, P Mistry, V Menon - Nature Communications, 2021 - nature.com
Restricted and repetitive behaviors (RRBs) are a defining clinical feature of autism spectrum
disorders (ASD). RRBs are highly heterogeneous with variable expression of circumscribed …