Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …

Cardiovascular diseases are the most common cause of death in the world. One of the major
causes of cardiac death is excessive apoptosis. However, multiple pathways through …

Pumpkin (Cucurbita moschata) is a popular and nutritious vegetable consumed worldwide.
The overall purpose of this study was to evaluate the effects of C. moschata fruit extract …

Current therapy of pulmonary arterial hypertension (PAH) is inadequate.
Dehydroepiandrosterone (DHEA) effectively treats experimental pulmonary hypertension in …

Diabetic cardiomyopathy is known as an essential complication of diabetes, a main reason
leading to mortality for diabetic patients, and novel therapeutic strategies for treatment are …

Myocardial fibrosis is a significant pathological basis of heart failure. Overactivation of the
ERK1/2 and JNK1/2 signaling pathways of MAPK family members synergistically promotes …

Regular running and strength training are the best ways to improve aerobic capacity and
develop the size of skeletal muscles. However, uncontrolled physical activities can often …

BACKGROUND: The present study evaluated the effects of aerobic training with variable
intensities on apoptotic indices of cardiac tissue in fatty diabetic rats. METHODS: Twenty …

A plethora of studies have demonstrated the expression of cytochrome P450 (CYP) and
soluble epoxide hydrolase (sEH) enzymes in the heart and other cardiovascular tissues. In …

Non-specific inhibition of Rho-associated kinases (ROCKs) alleviated renal fibrosis in the
unilateral ureteral obstruction (UUO) model, while genetic deletion of ROCK1 did not affect …