Selenoproteins: molecular pathways and physiological roles
VM Labunskyy, DL Hatfield… - Physiological …, 2014 - journals.physiology.org
Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …
relevance to several pathophysiological conditions. The biological effects of selenium are …
Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling
EM Hanschmann, JR Godoy, C Berndt… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism
H Liang, S He, J Yang, X Jia, P Wang, X Chen, Z Zhang… - Cell metabolism, 2014 - cell.com
PTEN is one of the most frequently mutated genes in human cancer. It is known that PTEN
has a wide range of biological functions beyond tumor suppression. Here, we report that …
has a wide range of biological functions beyond tumor suppression. Here, we report that …
Composition and evolution of the vertebrate and mammalian selenoproteomes
M Mariotti, PG Ridge, Y Zhang, AV Lobanov… - PloS one, 2012 - journals.plos.org
Background Selenium is an essential trace element in mammals due to its presence in
proteins in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing …
proteins in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing …
Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences
In eukaryotes, it is generally assumed that translation initiation occurs at the AUG codon
closest to the messenger RNA 5′ cap. However, in certain cases, initiation can occur at …
closest to the messenger RNA 5′ cap. However, in certain cases, initiation can occur at …
Regulation of redox signaling by selenoproteins
The unique chemistry of oxygen has been both a resource and threat for life on Earth for at
least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more …
least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more …
Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini
Translation initiation generally occurs at AUG codons in eukaryotes, although it has been
shown that non-AUG or noncanonical translation initiation can also occur. However, the …
shown that non-AUG or noncanonical translation initiation can also occur. However, the …
Critical Roles of the Cysteine–Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System
J Fujii, T Osaki, Y Soma, Y Matsuda - International Journal of Molecular …, 2023 - mdpi.com
γ-Glutamyl moiety that is attached to the cysteine (Cys) residue in glutathione (GSH) protects
it from peptidase-mediated degradation. The sulfhydryl group of the Cys residue represents …
it from peptidase-mediated degradation. The sulfhydryl group of the Cys residue represents …
A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking
Calcium signaling is critical for successful fertilization. In spermatozoa, calcium influx into the
sperm flagella mediated by the sperm-specific CatSper calcium channel is necessary for …
sperm flagella mediated by the sperm-specific CatSper calcium channel is necessary for …