No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …

Central nervous system (CNS) diseases have become one of the leading causes of death in
the global population. The pathogenesis of CNS diseases is complicated, so it is important …

Over the past two decades, advances in droplet-based microfluidics have facilitated new
approaches to process and analyze samples with unprecedented levels of precision and …

The growing availability of single-cell and spatially resolved transcriptomics has led to the
development of many approaches to infer cell–cell communication, each capturing only a …

Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

Single-cell or single-nucleus transcriptomics is a powerful tool for identifying cell types and
cell states. However, hypotheses derived from these assays, including gene expression …

Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases,
including multiple sclerosis and experimental autoimmune encephalomyelitis,,,,,,–(EAE), an …