RNA plays a myriad of roles in the body including the coding, decoding, regulation, and
expression of genes. RNA oligonucleotides have garnered significant interest as …

Figures released in 2013 by the International Diabetes Federation (IDF) state that over 382
million individuals worldwide are affected by diabetes mellitus (DM). 1 The global …

Nucleic acids are getting increased attention to fulfill unmet medical needs. The past five
years have seen more than ten FDA approvals of nucleic acid based therapeutics. New …

Huntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended
trinucleotide CAG repetition in the HTT gene. Wild-type huntingtin protein (HTT) is essential …

Despite the progress made in the diagnoses and therapy of gastrointestinal cancers, these
diseases are still plagued by a high mortality. Thus, novel therapeutic approaches are …

The identification of RNA interference (RNAi) has caused a growing interest in harnessing
its potential in the treatment of different diseases. Modulation of dysregulated genes through …

Background The delivery of therapeutic nucleic acids, such as small interfering RNA (siRNA)
and antisense oligonucleotides (ASO) into cells, is widely used in gene therapy. Gold …

The “click” characteristics of nucleophilic opening of epoxide have recently been exploited
for the development of a functional hydrogel particle system based on commercially …

The ability of oligonucleotides to silence specific genes or inhibit the biological activity of
specific proteins has generated great interest in their use as research tools and therapeutic …

We present the hydrolysis reversible acylation of RNA 2'-OH for functional control.
Compared with previously reported acylating reagents, our new molecule EST1A eliminated …