G protein-coupled receptors (GPCRs) are seven transmembrane helical bundle proteins
(Figure 1) found on the surface of all cells. 1-3 They mediate cellular responses to a diverse …

Membrane nanoobjects are very important tools to study biomembrane properties. Two
types are described herein: Bicelles and Nanodiscs. Bicelles are obtained by thorough …

Molecular imprinting of morphine and the endogenous neuropeptide [Leu5] enkephalin (Leu-
enkephalin) in methacrylic acid-ethylene glycol dimethacrylate copolymers is described …

The structure of the dynorphin (1–13) peptide (dynorphin) bound to the human kappa opioid
receptor (KOR) has been determined by liquid-state NMR spectroscopy. 1H and 15N …

Ghrelin plays a central role in controlling major biological processes. As for other G protein-
coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to …

The solution structure of human salivary histatin 5 (D‐S‐H‐A‐K‐R‐H‐H‐G‐Y‐K‐R‐K‐F‐H‐E‐
K‐H‐H‐S‐H‐R‐G‐Y) was examined in water (pH 3.8) and dimethyl sulfoxide solutions using …

Major biological processes occur at the biological membrane. One of the great challenges is
to understand the function of chemical or biological molecules inside the membrane; as well …

Conformational searches by molecular dynamics and different types of Monte Carlo or build-
up methods usually aim to find the lowest-energy conformation. However, this is often …

Enkephalins are pentapeptides found in the central nervous system. It is believed that these
neuropeptides interact with the nerve cell membrane to adopt a conformation suitable for …

The ideas developed in the Membrane Compartments Theory which allow a quantitative
prediction of receptor preference are discussed in terms of our present knowledge of opioid …