Selenium (Se) is an essential micronutrient of organism and has important function. It
participates in the functions of selenoprotein in several manners. In recent years, Se has …

The high number of new cancer incidences and the associated mortality continue to be
alarming, leading to the search for new therapies that would be more effective and less …

Selenium (Se) acts as an essential trace element in the human body due to its unique
biological functions, particularly in the oxidation-reduction system. Although several clinical …

Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a
multifunctional compound, which catalyzes several essential reactions for the protection of …

Organo-seleno compounds (org-Se) have been widely used in antitumor, antiviral, and
antiinflammatory therapy; antioxidation and other biological fields. As such, they have made …

Reactive oxygen species (ROS) are a group of highly reactive chemicals under tight control
of intracellular antioxidants. The balance in oxidation-antioxidation is essential for …

Glioblastoma multiforme (GBM) is the most malignant and aggressive primary brain tumor in
adults. Despite concerted efforts to improve current therapies, the prognosis of glioblastoma …

Glioblastoma multiforme (GBM) are resistant to TNFα-induced apoptosis and blockade of
TNFα-induced NF-κB activation sensitizes glioma cells to apoptosis. As Casein kinase-2 …

Identification of novel target pathways in glioblastoma (GBM) remains critical due to poor
prognosis, inefficient therapies and recurrence associated with these tumors. In this work …

Ebselen is a synthetic, lipid-soluble seleno-organic compound. The high electrophilicity of
ebselen enables it to react with multiple cysteine residues of various proteins. Despite …