Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Embryonic gene expression intricately reflects anatomical context, developmental stage,
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …

Cardiogenesis is an exquisitely sensitive process. Any perturbation in the cells that
contribute to the building of the heart leads to cardiac malformations, which frequently result …

The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …

The Notch pathway is a crucial cell-fate regulator in the developing heart. Attention in the
past centered on Notch function in cardiomyocytes. However, recent advances demonstrate …

The sinoatrial node initiates the heartbeat and controls the rate and rhythm of contraction,
thus serving as the pacemaker of the heart. Despite the crucial role of the sinoatrial node in …

Cardiac chamber formation represents an essential evolutionary milestone that allows for
the heart to receive (atrium) and pump (ventricle) blood throughout a closed circulatory …