Traditional annotation of protein-encoding genes relied on assumptions, such as one open
reading frame (ORF) encodes one protein and minimal lengths for translated proteins. With …

Macrolides represent a large family of protein synthesis inhibitors of great clinical interest
due to their applicability to human medicine. Macrolides are composed of a macrocyclic …

Nascent polypeptide chains can induce translational stalling to regulate gene expression.
This is exemplified by the E. coli secretion monitor (SecM) arrest peptide that induces …

Ribosome movement is not always smooth and is rather often impeded. For ribosome
pauses, fundamental issues remain to be addressed, including where ribosomes pause on …

The timely production of functional proteins is of critical importance for the biological activity
of cells. To reach the functional state, newly synthesized polypeptides have to become …

Translation initiation is a major rate-limiting step for protein synthesis. However, recent
studies strongly suggest that the efficiency of protein synthesis is additionally regulated by …

Marina V. Rodnina is the winner of the 2015 Hans Neurath Award. Abstract The cellular
proteome is shaped by the combined activities of the gene expression and quality control …

Co-translational protein folding is an essential process by which cells ensure the safe and
efficient production and assembly of new proteins in their functional native states following …

RNA can fold back on itself to adopt a wide range of structures. These range from relatively
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …

Ribosome-associated quality control (RQC) represents a rescue pathway in eukaryotic cells
that is triggered upon translational stalling. Collided ribosomes are recognized for …