As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

The resurgence of research into cancer metabolism has recently broadened interests
beyond glucose and the Warburg effect to other nutrients, including glutamine. Because …

Abstract Glutamine synthase 2 (GLS2) is a key regulator of glutaminolysis and has been
previously implicated in activities consistent with tumor suppression. Here we generated …

Glutamine is an abundant and versatile nutrient that participates in energy formation, redox
homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics …

Metabolic reprogramming, characterized by alterations of cellular metabolic patterns, is
fundamentally important in supporting the malignant behaviors of cancer cells. It is …

Many tumors increase uptake and dependence on glucose, cystine or glutamine. These
basic observations on cancer cell metabolism have opened multiple new diagnostic and …

Anabolic biosynthesis requires precursors supplied by the Krebs cycle, which in turn
requires anaplerosis to replenish precursor intermediates. The major anaplerotic sources …

A handful of tumor-derived cell lines form the mainstay of cancer therapeutic development,
yielding drugs with an impact typically measured as months to disease progression. To …

Several decades of research have sought to characterize tumor cell metabolism in the hope
that tumor-specific activities can be exploited to treat cancer. Having originated from …

Altered glucose metabolism in cancer cells is termed the Warburg effect, which describes
the propensity of most cancer cells to take up glucose avidly and convert it primarily to …