Human PON1 is a HDL-associated lipolactonase capable of preventing LDL and cell
membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to …

Organophosphorus compounds are extensively used worldwide as pesticides which cause
great hazards to human health. Nerve agents, a subcategory of the organophosphorus …

Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

Paraoxonase-1 (PON1) is a high-density lipoprotein-associated esterase and is speculated
to play a role in several human diseases including diabetes mellitus and atherosclerosis …

PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with
various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity …

Oxidant–antioxidant imbalance is involved in the etiology of different diseases, including
cardiovascular diseases (CVDs), liver disorders, kidney diseases, cancers and diabetes …

Large numbers of inbred laboratory rat strains have been developed for a range of complex
disease phenotypes. To gain insights into the evolutionary pressures underlying selection …

Despite a growing body of evidence, the role of the gut microbiome in cardiovascular
diseases is still unclear. Here, we present a systems-genome-wide and metagenome-wide …

Pomegranate is an ancient fruit that is still part of the diet in the Mediterranean area, the
Middle East, and India. Health-promoting effects have long been attributed to this fruit …

A Mediterranean diet rich in olive oil has been associated with health benefits in humans. It
is unclear if and to what extent olive oil phenolics may mediate these health benefits. In this …