Multiple sources of evidence support a role for diminished dopaminergic neurotrans-mission
in major depression. The physiological alterations underlying reduced dopa-mine (DA) …

About one million suicides and ten million suicide attempts occur worldwide each year.
Suicide is not simply a response to stress, but generally a complication of a psychiatric …

The disruptive behavior of persons with dementia is a problem of considerable clinical
interest and growing scientific concern. This paper offers a view of these behaviors as …

In Parkinson's disease (PD), in addition to degeneration of the nigrostriatal dopaminergic
pathway, a variety of neuronal systems are involved, causing multiple neuromediator …

Serotonin (5-HT) neuron and neurotransmitter loss in normal aging and neuropsychiatric
diseases of late life may contribute to behavioral changes commonly observed in the elderly …

Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates
cognitive functions and primarily affects associated brain regions involved in learning and …

Background Major depression and suicide are associated with fewer serotonin transporter
(5-HTT) sites. The 5′-flanking promoter region of the 5-HTT gene has a biallelic …

Objective Suicide is a major public health concern as each year 30000 people die by
suicide in the USA alone. In the teenage population, it is the second leading cause of death …

Depressive disorders (DDs) are the most common type of psychiatric co-morbidity in patients
with epilepsy. They are more likely to occur in patients with partial seizure disorders of …

Numerous abnormalities have been found in the serotonergic system in suicide attempters
and completers. There is considerable evidence that the serotonergic system is partly under …