Impact of endemic infections on HIV susceptibility in sub-Saharan Africa

S Yegorov, V Joag, RM Galiwango, SV Good… - … , Travel Medicine and …, 2019 - Springer
Human immunodeficiency virus (HIV) remains a leading cause of global morbidity with the
highest burden in Sub-Saharan Africa (SSA). For reasons that are incompletely understood …

Impact of helminth infections on female reproductive health and associated diseases

A Chetty, MA Omondi, C Butters, KA Smith… - Frontiers in …, 2020 - frontiersin.org
A growing body of knowledge exists on the influence of helminth infections on allergies and
unrelated infections in the lung and g astro i ntestinal (GI) mucosa. However, the bystander …

Helminth antigens differentially modulate the activation of CD4+ and CD8+ T lymphocytes of convalescent COVID-19 patients in vitro

T Adjobimey, J Meyer, V Terkeš, M Parcina, A Hoerauf - BMC medicine, 2022 - Springer
Background The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by
SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly …

Helminth Infection–Induced Increase in Virtual Memory CD8 T Cells Is Transient, Driven by IL-15, and Absent in Aged Mice

T Hussain, A Nguyen, C Daunt, D Thiele… - The Journal of …, 2023 - journals.aai.org
Abstract CD8 virtual memory T (T VM) cells are Ag-naive CD8 T cells that have undergone
partial differentiation in response to common γ-chain cytokines, particularly IL-15 and IL-4. T …

Depletion and activation of mucosal CD4 T cells in HIV infected women with HPV-associated lesions of the cervix uteri

W Mbuya, R Mcharo, J Mhizde, J Mnkai, A Mahenge… - PLoS …, 2020 - journals.plos.org
Background The burden of HPV-associated premalignant and malignant cervical lesions
remains high in HIV+ women even under ART treatment. In order to identify possible …

Distinct Immune Profiles of Exhausted Effector and Memory CD8+ T Cells in Individuals With Filarial Lymphedema

S Horn, D Borrero-Wolff, M Ritter, K Arndts… - Frontiers in Cellular …, 2021 - frontiersin.org
CD8+ T cells are crucial for the clearance of viral infections, and current research begins to
highlight their importance in parasitic diseases too. In-depth research about characteristics …

Contribution of the TIM-3/Gal-9 immune checkpoint to tropical parasitic diseases

C Bailly - Acta Tropica, 2023 - Elsevier
Neglected tropical parasitic diseases (NTD) are prevalent in many countries and cost-
effective treatments remain urgently needed. Novel approaches have been proposed to …

[HTML][HTML] Filarial lymphedema patients are characterized by exhausted CD4+ T cells

S Horn, M Ritter, K Arndts, D Borrero-Wolff… - Frontiers in Cellular …, 2022 - frontiersin.org
Worldwide, more than 200 million people are infected with filariae which can cause severe
symptoms leading to reduced quality of life and contribute to disability-adjusted life years …

Filariasis research–from basic research to drug development and novel diagnostics, over a decade of research at the Institute for Medical Microbiology, Immunology …

I Karunakaran, M Ritter, K Pfarr… - Frontiers in tropical …, 2023 - frontiersin.org
Filariae are vector borne parasitic nematodes, endemic in tropical and subtropical regions
causing avoidable infections ranging from asymptomatic to stigmatizing and disfiguring …

Hookworm infection associates with a vaginal Type 1/Type 2 immune signature and increased HPV load

MA Omondi, EH Kamassa, G Katawa… - Frontiers in …, 2022 - frontiersin.org
Helminth infection-driven changes to immunity in the female reproductive tract (FRT) is an
immune axis that is currently understudied but can have major implications for the control of …