Hemorrhagic transformation after ischemic stroke in animals and humans

GC Jickling, DZ Liu, B Stamova… - Journal of Cerebral …, 2014 - journals.sagepub.com
Hemorrhagic transformation (HT) is a common complication of ischemic stroke that is
exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are …

[HTML][HTML] Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

S Ohta - Pharmacology & therapeutics, 2014 - Elsevier
Molecular hydrogen (H 2) has been accepted to be an inert and nonfunctional molecule in
our body. We have turned this concept by demonstrating that H 2 reacts with strong oxidants …

Beneficial biological effects and the underlying mechanisms of molecular hydrogen-comprehensive review of 321 original articles

M Ichihara, S Sobue, M Ito, M Ito, M Hirayama… - Medical gas …, 2015 - Springer
Therapeutic effects of molecular hydrogen for a wide range of disease models and human
diseases have been investigated since 2007. A total of 321 original articles have been …

Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications

S Ohta - Current pharmaceutical design, 2011 - ingentaconnect.com
Persistent oxidative stress is one of the major causes of most lifestyle-related diseases,
cancer and the aging process. Acute oxidative stress directly causes serious damage to …

Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications

S Ohta - Methods in enzymology, 2015 - Elsevier
Molecular hydrogen (H 2) was believed to be inert and nonfunctional in mammalian cells.
We overturned this concept by demonstrating that H 2 reacts with highly reactive oxidants …

[HTML][HTML] Advanced research on the health benefit of reduced water

S Shirahata, T Hamasaki, K Teruya - Trends in Food Science & Technology, 2012 - Elsevier
In Japan, research on functional water, especially on reduced water, is developing at a rapid
pace. Reduced water such as electrochemically reduced water and natural reduced water …

Delineation of neuroprotective effects and possible benefits of antioxidantstherapy for the treatment of Alzheimer's diseases by targeting mitochondrial-derived …

V Walia, D Kaushik, V Mittal, K Kumar, R Verma… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is considered the sixth leading cause of death in elderly patients
and is characterized by progressive neuronal degeneration and impairment in memory …

Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases

K Ohno, M Ito, M Ichihara, M Ito - Oxidative medicine and …, 2012 - Wiley Online Library
Effects of molecular hydrogen on various diseases have been documented for 63 disease
models and human diseases in the past four and a half years. Most studies have been …

Magnesium alloys as degradable biomaterials

Y Zheng - 2015 - books.google.com
This book provides a comprehensive review of the biomedical applications of biodegradable
magnesium and its alloys. It discusses the basic concepts of biodegradation mechanisms as …

Hydrogen as a selective antioxidant: a review of clinical and experimental studies

Y Hong, S Chen, JM Zhang - Journal of International …, 2010 - journals.sagepub.com
Oxidative stress is implicated in the pathogenesis of many diseases; however, currently
used antioxidants have a high toxicity that constrains administration to a narrow window of …